Pain Dictionary

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Fibroblast
A connective tissue cell that secretes proteins and especially molecular collagen from which connective tissue is developed.

Film dressings
Used as primary of secondary dressing. Semi-permeable films are made of clear polyurethane coated with an adhesive. They are conformable and resistant to shear and tear. They prevent bacterial colonisation but do not absorb exudate.

Fibrin
Fibrin is produced from fibrinogen by proteolytic removal of the highly charged fibrinopeptides by thrombin, in the presence of calcium ions. The fibrin gel, formed during blood clotting (fibrin clot), acts as a haemostatic plug, and matrix for early wound healing.

Fibrin clot / fibrin matrix
See Fibrin.

Fibrinogen
A soluble blood plasma protein that is the precursor protein of fibrin.

Fibroblast
Resident cell of connective tissue that secretes ECM components (fibrillar procollagen,elastin, fibronectin and ECM polysaccharides) and necessary proteinases and cell signals. Fibroblasts numbers increase in injured tissue where they respond to chemotactic stimuli. Fibroblasts also stimulate cell migration, angiogenesis, soft tissue growth and repair.

Fibronectin
An adhesion protein produced mainly by fibroblasts and macrophages. It is a glycoprotein that occurs in insoluble fibrillar form in the extracellular matrix of animal tissues, and soluble in blood plasma. Fibronectins have multiple functions that confer the ability of cells to interact with many extracellular substances such as collagen, fibrin and heparin, and also with specific cell surface receptors on responsive cells.

Foam dressing
A dressing produced from polyurethane a soft, open cell sheets and may be single layer or multiple layers. They are non-adherent, can absorb large amounts of exudate and can also be used as secondary dressings. They are also available impregnated with charcoal and with a waterproof backing.